Cancer Metabolism · Metabolomics · Mass Spectrometry

Unraveling the
metabolic basis
of human cancer.

I'm a metabolomics scientist and bioanalytical chemist. My work uses high-resolution mass spectrometry and multi-omics integration to decode how cancer rewires human metabolism — towards earlier diagnostics and new therapeutic targets.

2025 · iMetaOmics

Novel Machine-Learning Bioinformatics Reveal Distinct Metabolic Alterations for Enhanced Colorectal Cancer Diagnosis and Monitoring

Xu R, Jung H, Choueiry F, Zhang S, Pearlman R, Hampel H, Jin N, Li J, Zhu J

iMetaOmics, 2025

Machine Learning Colorectal Cancer LC-MS PLS-DA / ANN

2024 · AACR Annual Meeting

Molecular Biomarkers of Non-Hodgkin Lymphomas and Subtypes Identified by Mass Spectrometry-Based Metabolomics

Choueiry FM, Singh S, Sehgal L, Zhu J

Cancer Journal / AACR, 2024

Lymphoma Mass Spectrometry Biomarker Discovery

2022 · Cancers · State-of-the-Art Review

The Application of Metabolomics in Recent Colorectal Cancer Studies

Gold A, Choueiry F, Jin N, Mo X, Zhu J

Cancers, 14(3):725, 2022

Colorectal Cancer Systematic Review GC-MS / LC-MS Gut Microbiome

2022 · Experimental Biology and Medicine

Analyses of Lung Cancer-Derived Volatiles in Exhaled Breath and In Vitro Models

Choueiry F, Barham A, Zhu J

Experimental Biology and Medicine, 247(13):1179–1190, 2022

Lung Cancer Volatilomics Exhaled Breath VOC Biomarkers

2021 · Cancers

Integration of Metabolomics and Gene Expression Profiling Elucidates IL4I1 as Modulator of Ibrutinib Resistance in ABC-Diffuse Large B Cell Lymphoma

Choueiry F, Singh S, Sircar A, Laliotis G, Sun X, Chavdoula E, Zhang S, Helmig-Mason J, Hart A, Epperla N, Tsichlis P, Baiocchi R, Alinari L, Zhu J, Sehgal L

Cancers, 13(9):2146, 2021

DLBCL Multi-Omics Drug Resistance Ibrutinib OXPHOS Reprogramming

2021 · Analytica Chimica Acta

SESI-HRMS Fingerprinting Enabled Treatment Monitoring of Pulmonary Carcinoma Cells in Real-Time

Choueiry F, Zhu J

Analytica Chimica Acta, 1189:339230, 2021

Lung Cancer SESI-HRMS Real-Time Monitoring Volatilomics
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I'm Fouad Choueiry, PhD, a metabolomics scientist and bioanalytical chemist specializing in cancer metabolism and human disease. I completed my doctoral studies at The Ohio State University in March 2024 within the Zhu Lab at the James Comprehensive Cancer Center, where I developed and applied high-resolution mass spectrometry tools to understand how cancer rewires human metabolism.

My research spans targeted and untargeted LC-MS/MS metabolomics, real-time volatilomics via SESI-HRMS, and multi-omics data integration — connecting metabolome alterations to transcriptomic signals to identify disease mechanisms and actionable biomarkers. I've applied these approaches across colorectal cancer, non-Hodgkin lymphoma, lung cancer, and drug resistance biology.

I'm now based at UC Berkeley, continuing to advance metabolomics methods at the intersection of analytical chemistry and disease biology.

My current work extends into emerging frontiers of the field: the development of protein binding assays coupled with mass spectrometry to characterize small molecule–protein interactions at biochemical resolution, subcellular metabolomics to map metabolite distributions across organelle compartments, and single-cell metabolomics — pushing the sensitivity limits of mass spectrometry to resolve metabolic heterogeneity at the level of individual cells, with direct implications for understanding tumor microenvironments and cell-state transitions in disease.

I approach science as an interdisciplinary bioanalytical chemist — equally at home building wet-lab LC-MS methods and developing computational pipelines to extract biological meaning from complex, high-dimensional metabolomics data.